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Megan
Hi,
I am 51 and reached menopause 1.5 years ago, with all the fun pre-menopause conditions. One thing I did was read a lot. I learned that studies have shown that soy causes infertility in lab tests on animals, (sheep). Considering infertility and the popularity of soy milk, protein, meal bars, etc. it may be worth doing your own homework if you frequently intake soy, and are within child bearing years.

FYI

Megan
John Bobbin BNat
Hi Megan,
I have seen a lot of research that showed excellent results for soy. Soy doesn't appear to have had much effect on the breeding of the Chinese does it? I think they are pretty fertile.

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mindongers
The 24-hour dietary recalls, taken up to eight times with an average four months between the measurements, showed that the average intake of soybeans and isoflavones was 39 g and 8 mg per day, respectively.

Song and co-workers report that every one milligram of isoflavone intake was associated with a 0.26 per cent increase in bone mineral density per year in the neck of the femur, and a 0.31 per cent increase in the Ward's triangle area of the femur.

"Habitual soybean intake was low in this study though, and other dietary components also affect bone metabolism," cautioned the researchers.





Ovarian Cysts No More
John Bobbin BNat
Hi Megan,
There are a lot of interesting studies on illness and diet possibly implicating soy either positively or negatively on the internet. Alzhiemers is lower amongst mainland Japanese compared to American Japanese, I find this interesting but one swallow does not make a summer so we probably need to look at many studies to see if this trend is supported by other research.

Study Yields New Clues for Alzheimer's Disease

Several recent studies have begun to define the involvement of certain genes in the development of Alzheimer's disease. But a new study comparing the occurrence of dementia and Alzheimer's disease among different populations suggests there may be other risk factors for Alzheimer's disease that vary across cultures and nations.

According to an analysis by scientists at the National Institute on Aging (NIA), the University of Hawaii, and the Honolulu Department of Veteran s Affairs, Japanese-American men living in Hawaii have a high rate of Alzheimer's disease -- 5.4 percent in this study population -- when compared with levels found in several studies of men of similar age living in Japan.

In Japan, rates of Alzheimer's disease are relatively low compared with rates found in the U.S., but the Japanese have higher rates of vascular dementia, another form of dementing illness. According to the new study, first and second generation Japanese-American men who have lived all or most of their lives in Hawaii appear to have a higher risk of Alzheimer's disease, a risk similar to that of European-ancestry Americans. They have not, however, experienced any decrease in their risk of vascular dementia.

Observations from the new study will guide a search for environmental, genetic, and cultural factors that may influence the development of both Alzheimer's disease and vascular dementia.

The study appears in the September 25 issue of the Journal of the American Medical Association. Researchers examined data on 3,734 men aged 71-93. About 9.3 percent of the participants overall were categorized as having dementia. Some 4.2 percent of the Japanese-American men had vascular dementia.

The risk for developing vascular dementia seems unchanged in this population. At the same time, something associated with migration or with exposure to Western environmental factors has led to higher rates of Alzheimer's disease, says Lon White, M.D., chief of the NIA s Asia-Pacific Office and the study s director. Further research in this population, and other cross-national research, should help us identify what those factors may be.

Reporters wishing to contact White for interviews should call the NIA Public Information Office at 301-496-1752. Please note that Hawaiian time is 6 hours earlier than U.S. Eastern Daylight Time

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As a contrast to this last post I have added Australian statistics.

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Australian Statistics

Numbers

* In 2008, there are currently 227,300 people with dementia, with the number expected to be 731,000 by 2050 unless there is a medical breakthrough.
* In Australia there will be an estimated 57,000 new cases of dementia in 2008.
* Dementia can affect younger people; currently over 9,600 Australians under the age of 65 have younger onset dementia.
* Between 2000 and 2050, the number of people with dementia in Australia is expected to increase by 327%, while the total population increases by less than 40%.
* Dementia is a major determining factor in precipitating entry to residential care. At least 60% of people in high care facilities and 30% of people in low care facilities have dementia. Many more have an obvious cognitive impairment (90% high care; 54% low care).
* Currently some 12.4% of Australians with dementia – around one in 8 – do not speak English at home, ranging from 21% in NT to 3.5% in Tasmania. Overall in the period 2001 to 2050 there is projected to be a fall in the proportion of Australians with dementia speaking English (83.8% to 82.4%) and other European languages (7.6% to 6.0%), with a greater proportion speaking Asian (6.0% to 8.3%) and Middle Eastern (1.8% to 2.3%) languages.
*
There are approx 2100 indigenous people aged 45 and over in the Kimberley region, WA. Latest research has shown the prevalence of dementia in this group is 12.4%, compared to a rate of 2.6% in the Australian population – nearly five times higher. The prevalence was higher in males – in the general community, the rate is generally higher among females.

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John Bobbin BNat
Hi
Soy may effect men as well if this study is supported.



Oxford Journals
Hum. Reprod. Advance Access published online on July 23, 2008
Human Reproduction, doi:10.1093/hum

© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic
Jorge E. Chavarro1,2,7, Thomas L. Toth3, Sonita M. Sadio4 and Russ Hauser3,5,6

1 Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA, USA 2 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA 3 Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 4 Department of Urology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 5 Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA 6 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

7 Correspondence address. Tel: +1-617-432-4584; Fax: +1-617-432-2435; E-mail: jchavarr@hsph.harvard.edu

BACKGROUND: High isoflavone intake has been related to decreased fertility in animal studies, but data in humans are scarce. Thus, we examined the association of soy foods and isoflavones intake with semen quality parameters.

METHODS: The intake of 15 soy-based foods in the previous 3 months was assessed for 99 male partners of subfertile couples who presented for semen analyses to the Massachusetts General Hospital Fertility Center. Linear and quantile regression were used to determine the association of soy foods and isoflavones intake with semen quality parameters while adjusting for personal characteristics.

RESULTS: There was an inverse association between soy food intake and sperm concentration that remained significant after accounting for age, abstinence time, body mass index, caffeine and alcohol intake and smoking. In the multivariate-adjusted analyses, men in the highest category of soy food intake had 41 million sperm/ml less than men who did not consume soy foods (95% confidence interval = –74, –8; P, trend = 0.02). Results for individual soy isoflavones were similar to the results for soy foods and were strongest for glycitein, but did not reach statistical significance. The inverse relation between soy food intake and sperm concentration was more pronounced in the high end of the distribution (90th and 75th percentile) and among overweight or obese men. Soy food and soy isoflavone intake were unrelated to sperm motility, sperm morphology or ejaculate volume.

CONCLUSIONS: These data suggest that higher intake of soy foods and soy isoflavones is associated with lower sperm concentration.

Key words: soy/isoflavones/semen analysis/sperm concentration/infertility

Submitted on March 3, 2008; resubmitted on April 18, 2008; accepted on April 28, 2008
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