Natural Medical Breakthrough for the 21st Century

In the early 1980's, Dr. Gustavo Bounous, a world renowned
research scientist, noticed that one group of his lab
animals was living, on average, 35% longer than the others.
His work in the field of health and nutrition had been
comparing the food value of various proteins but this
observation redirected his entire course of investigation.
He didn't know how it happened or why it happened but that
it did happen over and over again. The animals being given
one specific whey protein concentrate (WPC) were outliving
all others.
But Why?

The first question that Dr. Bounous attacked was the cause
of death in the animals that died first. If he didn't know
why the one group lived longer, perhaps he could determine
why the other group died at younger ages. His post-mortems
revealed an astonishing fact. The animals receiving the WPC
protein did not die of the same things that killed the
other groups of animals. The younger animals died of
strokes and cancers while the WPC fed animals did not.

But Why?

Why didn't the WPC group have strokes and cancers? Was
there something in the WPC that helped prevent them? The
next series of tests answered that question. The animals
were exposed to a known cancer causing substance. The
animals in the WPC group showed much lower susceptibility
to tumors. Their tumors were much smaller and less
frequent. The WPC fed group had some sort of resistance to
the cancers. The doctor then altered his test. He didn't
give any animals the WPC protein and exposed the entire
group to the same cancer causing substance. For 20 weeks,
there was no protective WPC given. Then one group of
animals was switched to the WPC protein diet. The post-
mortems were astonishing. The WPC fed group again had
smaller and fewer tumors. The WPC protein was proven to
both reduce the incidence of new cancers (prevention) and
to substantially slow or reverse the growth of existing
tumors (treatment)!

But Why?

Dr. Bounous had indeed found something of value, a
substance that would inhibit cancer in lab animals but he
still didn't know how or why. One afternoon, during one his
very infrequent coffee breaks, Dr. Bounous happened to meet
a fellow scientist from the other end of the same medical
building complex. During what started as a short break,
they discussed their respective work - Dr. Bounous work in
nutrition and his remarkable findings and Dr. Batist, a
young researcher working on something called glutathione
and it's possible role in cancer. Dr. Batist suggested that
what was happening appeared to be immune system enhancement
of the WPC group animals. Dr. Batist knew that cancer cells
had excessive levels of glutathione (GSH) and normal cells
had much lower levels. Using Dr. Batist's equipment, the
glutathione (GSH) levels of the lab animals were measured
and it was determined that the WPC supplement caused the
GSH levels in normal cells to go up (which was good) and
the GSH levels in cancer cells to go down (which was also
good).

Glutathione? There was already a great body of work
published about GSH in the medical literature. It was
already known that GSH is the body's own principal
antioxidant - that each cell in the body makes what it
needs when it's needed. It was already known that without
GSH, the other antioxidants (A, C, E, etc) can not function
efficiently. It was already known that GSH is a key
component of the liver's detoxification enzyme system, and
it was already known that GSH is the rate determining step
in the immune response system (the body's response to
infection). All this was known because medical science had
tested and observed the results of reducing GSH levels but
until now, there was no known way of raising GSH levels
throughout the body. HERE WAS THE BREAKTHROUGH! For the
first time, researchers were able to raise the levels of
GSH within the cells in a safe and convenient way. Then it
happened - disaster struck!! The WPC stopped working!!

But Why?

For nearly two years, Dr. Bounous and his team of
researchers went back over the results rechecking,
reanalyzing, reevaluating. They checked the equipment, the
animals, the testing procedures and the whey protein and
could find nothing that had changed. One evening, tired
from a long and frustrating day, Dr. Bounous was watching a
gormet cooking program on TV where two French chefs were
discussing cheese. One of them mentioned the difference in
the taste and texture of cheese since the pasteurization
process was changed. (In the late 1980's there was a
salmonella outbreak in Europe and the pasteurization
temperature of milk was raised from 63 C to 72 C
worldwide to better control the bacteria.) Since whey
protein was a byproduct of the cheese industry which was
itself a byproduct of milk processing, Dr. Bounous
theorized that the temperature could have had an effect. He
decided to create a supply of whey protein using the old
method of pasteurization for testing. The results proved
the theory - The bioactivity was back!

But Why?

During the retesting, everything was rechecked including
the composition of the whey protein. They contained the
same ingredients so what was the difference? The product
made at the lower temperature was undenatured. This
critical difference sets this WPC product apart from every
other WPC or protein supplement on the market. What does
undenatured mean? Undenatured means that the conformation
or sequence of components remains the same from raw
material to finished product. Think of a jar of colored
jellybeans representing the components of whey protein.
There are black, blue, red, yellow, green - a rainbow of
colors. Now visualize within that jar two orange jellybeans
stuck to a black jellybean - three stuck together. This is
the way bioactivity is achieved in nature. Two cysteine
amino acids are linked by a sulfur (thiol) bond - just like
the three jelly beans. For some reason, when the two linked
amino acids are swallowed, they are not separated. They
pass through digestion and absorption, circulate in the
blood stream, and are absorbed into our cells yet if they
are ingested separately (denatured), they are digested and
consumed before entering the cells. Think again of the
jellybeans. Only the two orange beans linked by a black are
active. High temperature pasteurization breaks the bond
holding them together. You still have a jar of jellybeans.
They look the same, they weigh the same and they taste the
same. They still have the same nutritional value, but the
key sequence is broken. The essential compound (cysteine)
is digested and never reaches the cells in active form. By
utilizing a patented low temperature / filtration process,
Dr. Bounous has developed a bioactive undenatured whey
protein concentrate.

And Then?


I don't want to bore you all with trivial talk.
My name is Randy I gather information and I pass it on to people like you.
The information I gather is focused on health and nutrition and how cellular strength plays a major role.
Instead of me trying to explain I will provide links to medical research in relation to health, nutrition and Glutathione.

I will start you with this one here...

http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=14988435

Observe the connection between Glutathione, Thioredoxin, Cystine and Cancer.

"Molecular pathogenesis and prevention of prostate cancer."
Anticancer Res. 2004 Mar-Apr;24(2B):553-4. Review.
PMID: 15160993 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.f...om_uid=15160993

"Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines." Br J Cancer. 2003 Mar 24;88(6):951-6.
PMID: 12644836 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.f...om_uid=12644836

Oxidative stress and regulation of glutathione in lung inflammation.
Eur Respir J. 2000 Sep;16(3):534-54. Review.
PMID: 11028671 [PubMed - indexed for MEDLINE]

Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease.
Am J Physiol. 1999 Dec;277(6 Pt 1):L1067-88. Review.
PMID: 10600876 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.f...om_uid=14988435


Please Post any and All Comments

Hi everyone. I would like to show you a bit of information on a natural way to defend against disease and help build better performing bodies.
Here is an abstract from the National Library of Medicine. I like to use information from this site because it is real and undisputed.

Therapeutic applications of whey protein.

Marshall K.

Master of Science, Social and Preventive Medicine, State University of New York at Buffalo; Graduate, National College of Naturopathic Medicine. Private practice, Sandpoint, Idaho Correspondence address: [Edited by Ian: Address and Email removed. Members on this forum can make contact via Email or PM function]


http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=15253675

Randy

Your Immune system or glutathione levels operate by being fed three amino acids, Glutamate, Glycine and Cystine. Glutamate and Glycine are derived from your daily diet, however Cystine comes mostly from eggs, milk and cheese.

In cooking of eggs and the process used for milk/cheese the composition of Cystine is changed to Cysteine, while still a valuable protein it no longer functions as a food for glutathione.
Immunotec has developed a method of extracting Cystine at its purest form, which in it's powdered form and mixed with a liquid of your choice, will directly feed the glutathione in your body and raise your immune system so that it can prevent and treat any disease that is immune system related.

Do You Know What "GLUTATHIONE" Is?

*The following conditions are all associated with low Glutathione levels: *

Acetaminophen poisoning, ADHD,
Addison's Disease, Aging, AIDS,
Alopecia, Areata, ALS,
Alzheimer's Disease, Anemia,
Anklosing, Spondylitis, Arteriosclerosis,
Arthritis, Asthma, Autism, Autoimmune Disease,
Bechet's Disease, Burns, Cacexia, Cancer, Candida,
Cardiomyopathy, Chronic Fatigue Syndrome, Colitis,
Coronary Artery Disease,
Cystic Fibrosis, Diabetes, Crohn's Disease, Eczema,
Emphysema, Epstein Barr Viral Syndrome,
Fibromyalgia, Free Radical Overload,
Goodpasture Syndrome, Graves' Disease,
Heavy Metal Poisoning, Liver Disease,
Hepatitis B, Hepatitis C, High Blood Cholesterol,
Herpes, Infertility, Infections (viral, bacterial and fungal),
Inflammatory Bowel Disease, Lupus,
Macular Degeneration, Malnutrition,
Meniere's Disease, Multiple Sclerosis,
Myasthenia Gravis, Neurodegenerative diseases,
Nutritional Disorders, Parkinson's Disease,
Pemphigus Vulgaris, Primary Biliary Cirrhosis,
Progeria, Psoriasis, Rheumatic Fever, Sarcoidosis,
Scleroderma, Shingles, Stroke, Surgery,
Toxic Poisoning, Trauma, Vasculitis, Vitiligo.

The "glutathione antioxidant system" is foremost among these internal protective systems because glutathione participates directly in the destruction of reactive oxygen compounds.
Interestingly glutathione also acts to reconstitute vitamins C and E after they have been oxidized, and therefore plays a determinant role in their function. Glutathione also plays a key role in the body?s defense against pollutants and ultraviolet radiation. It is thus not surprising that the highest concentration of glutathione is found in the liver which is the principal organ involved in the detoxification and elimination of toxic materials.
Through the action of GSH transferase, glutathione actually binds with the undesirable substances and is thus eliminated with them in the bile or the urine, creating a need for GSH replacement. Mankind is also being exposed to increasing amounts of ultraviolet radiation due to the thinning of the ozone layer. Here again glutathione plays a key role in neutralizing the oxiradicals produced by radiation such as the hydroxylradical which is the most reactive radical known to chemistry.
It is therefore quite apparent that the demand for glutathione precursors (cystine) in the diet is increasing, given how modern society is impacting the environment. Fortunately, through advances in technology it is now possible to obtain and consistently preserve in their original form, the specific cow?s milk proteins which share with predominant human milk proteins the same extremely rare glutathione promoting properties.

There is so much information available to you if you know where to look for it. Some or most people do not know what to look for and that is where I come in to help.

Please feel free to ask for help.
Randy Grover
[Edited by Ian: removed Email address. Members can contact each other using the forum's Email or PM function]

Neurotoxicology. 2005 Jan;26(1):1-8.

Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors.

James SJ, Slikker W 3rd, Melnyk S, New E, Pogribna M, Jernigan S.

Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, USA. jamesjill@uams.edu

More Here...
http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=15527868

Randy

The following conditions are all associated with low Glutathione levels:

Acetaminophen poisoning, ADHD,
Addison's Disease, Aging, AIDS,
Alopecia, Areata, ALS,
Alzheimer's Disease, Anemia,
Anklosing, Spondylitis, Arteriosclerosis,
Arthritis, Asthma, Autism, Autoimmune Disease,
Bechet's Disease, Burns, Cacexia, Cancer, Candida,
Cardiomyopathy, Chronic Fatigue Syndrome, Colitis,
Coronary Artery Disease,
Cystic Fibrosis, Diabetes, Crohn's Disease, Eczema,
Emphysema, Epstein Barr Viral Syndrome,
Fibromyalgia, Free Radical Overload,
Goodpasture Syndrome, Graves' Disease,
Heavy Metal Poisoning, Liver Disease,
Hepatitis B, Hepatitis C, High Blood Cholesterol,
Herpes, Infertility, Infections (viral, bacterial and fungal),
Inflammatory Bowel Disease, Lupus,
Macular Degeneration, Malnutrition,
Meniere's Disease, Multiple Sclerosis,
Myasthenia Gravis, Neurodegenerative diseases,
Nutritional Disorders, Parkinson's Disease,
Pemphigus Vulgaris, Primary Biliary Cirrhosis,
Progeria, Psoriasis, Rheumatic Fever, Sarcoidosis,
Scleroderma, Shingles, Stroke, Surgery,
Toxic Poisoning, Trauma, Vasculitis, Vitiligo.

If you or someone you know is suffering from one of the afflictions listed above, now is the time to build up your glutathione levels. If you are healthy, start maximizing your immune system. Healthy growth and activity of immune cells depend upon glutathione's availability.


"Brain cells die much more quickly when there's a drop in glutathione levels."

Learn more at ...Discovery.com
http://health.discovery.com/news/healthsco...d=518676&tid=30

Randy

Understanding Free Radicals and Antioxidants

What are free radicals? Why are they damaging to the human body? And how does vitamin E and the other antioxidant nutrients help protect the body against free radical damage? We?ll attempt to answer these questions and help you understand why eating 5-8 servings per day of anti-oxidant rich fruits and vegetables can benefit your health. But first, a little background?

Background: A Brief Look at Chemical Bonding
To understand the way that free radicals and antioxidants interact, you must first understand a bit about cells and molecules. So here's a (very) brief refresher course in Physiology/Chemistry 101: The human body is composed of many different types of cells. Cells are composed of many different types of molecules. Molecules consist of one or more atoms of one or more elements joined by chemical bonds.
As you probably remember from your old high school days, atoms consist of a nucleus, neutrons, protons and electrons. The number of protons (positively charged particles) in the atom?s nucleus determines the number of electrons (negatively charged particles) surrounding the atom. Electrons are involved in chemical reactions and are the substance that bonds atoms together to form molecules. Electrons surround, or "orbit" an atom in one or more shells. The innermost shell is full when it has two electrons. When the first shell is full, electrons begin to fill the second shell. When the second shell has eight electrons, it is full, and so on.
The most important structural feature of an atom for determining its chemical behavior is the number of electrons in its outer shell. A substance that has a full outer shell tends not to enter in chemical reactions (an inert substance). Because atoms seek to reach a state of maximum stability, an atom will try to fill it?s outer shell by:
gaining or losing electrons to either fill or empty its outer
shell sharing its electrons by bonding together with other atoms
in order to complete its outer shell.

Atoms often complete their outer shells by sharing electrons with other atoms. By sharing electrons, the atoms are bound together and satisfy the conditions of maximum stability for the molecule.

How Free Radicals are Formed
Normally, bonds don?t split in a way that leaves a molecule with an odd, unpaired electron. But when weak bonds split, free radicals are formed. Free radicals are very unstable and react quickly with other compounds, trying to capture the needed electron to gain stability. Generally, free radicals attack the nearest stable molecule, "stealing" its electron. When the "attacked" molecule loses its electron, it becomes a free radical itself, beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell.
Some free radicals arise normally during metabolism. Sometimes the body?s immune system?s cells purposefully create them to neutralize viruses and bacteria.
However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also spawn free radicals.
Normally, the body can handle free radicals, but if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur. Of particular importance is that free radical damage accumulates with age.

****************************************************

Antioxidants are a hot topic in current nutrition research and may be very important for athletes. Antioxidants are molecules believed to play a role in the prevention of such things as cancer and heart disease caused by free radicals. Free radicals are molecules that are missing a key component of their structure and are basically like skaters wearing one skate. Ideally they have two skates. With only one skate they can get around but they are unstable and potentially dangerous to themselves and anyone in their path. Antioxidants are the support crew that donates a skate to the one-legged radical to provide stability or that protects others from getting knocked down and damaged.
If free radicals choose to attack parts of fat molecules, they can start or contribute to heart disease. If they mess with DNA, they may contribute to cancer. During and after exercise, free radicals may cause tissue damage to muscles and contribute to fatigue. Antioxidants have the ability to diffuse these free radicals in a variety of ways. There is still much to learn about this process, but the benefits of consuming antioxidant-rich fruits and vegetables include lower risks of many chronic diseases and may include improved athletic performance.

Exercise and oxidative damage
Endurance exercise can increase oxygen utilization from 10 to 20 times over the resting state. This greatly increases the generation of free radicals, prompting concern about enhanced damage to muscles and other tissues. The question that arises is, how effectively can athletes defend against the increased free radicals resulting from exercise? Do athletes need to take extra antioxidants?
Because it is not possible to directly measure free radicals in the body, scientists have approached this question by measuring the by-products that result from free radical reactions. If the generation of free radicals exceeds the antioxidant defenses then one would expect to see more of these by-products. These measurements have been performed in athletes under a variety of conditions.
Antioxidant Activity of Whey
Several powerful antioxidants in whey have recently been discovered and examined. Dr. Eric A. Decker, from the University of Massachusetts, Amherst, discussed the antioxidant activity of two compounds found within whey proteins. Though he mentioned that milk proteins are not usually seen as being rich in antioxidants per se, it appears that whey is an exception.
His research found that the two antioxidants in whey proteins are of a low molecular weight, are water soluble, and are quite stable through processing. They also are able to inhibit a wide range of free radicals and such free radical-inducing catalysts as iron, lipooxygenase, singlet oxygen, ferryl radicals and hydroxyl radicals. The two antioxidants in whey were found to be active at physiological pH and to be able to tolerate a wide range of temperatures.
Dr. K.D. Kussendrager of DMV International, in the Netherlands, reviewed one of the most promising fractions of whey, lactoferrin, and its ability to strongly inhibit iron-dependent free radical reactions by directly binding to iron. This iron-binding ability of lactoferrin also results in the inhibition of bacteria growth. Kussendrager also talked about another fraction in whey called lactoperoxidase that appears to have strong anti-microbial, anti-viral and antioxidant properties.
Dr. J.P. Perraudin of Biopole, Brussels, Belgium, outlined the abilities of both lactoferrin and lactoperoxidase to prevent iron dependent free-radical reactions, prevent anemia, and stimulate the immune system. Lactoferrin has become a super-hot dietary supplement because of its immune-enhancing effects. Those taking whey protein receive a potent dose of lactoferrin with each 20-gram dose. Whey proteins have been shown to raise levels of the powerful antioxidant and immune stimulant glutathione. However, these research findings show that whey proteins have far more benefits than their ability to raise Glutathione.

Glutathione is a powerful antioxidant involved chiefly in liver detoxification. Research has indicated free-radical production normally results from the rise in oxygen consumption with exercise, and that glutathione levels can decrease with exercise.

Randy