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Anne Wilson

Research studies show fish oil benefits are down right amazing.

And knowing this is the second most important thing you can do for your health. (We'll get to #1 in importance soon.)

Studies are published almost daily as the scientific community discovers more and more of the many extraordinary omega 3 fish oil benefits.

If you haven't already been swept up in the net yet, here are 7 proven omega 3 benefits you should know about.

1. Less Pain and Inflammation. Omega 3 fatty acids, particularly EPA, have a very positive effect on your inflammatory response. Through several mechanisms, they regulate your body's inflammation cycle, which prevents and relieves painful conditions like arthritis, prostatitis, cystitis and anything else ending in "itis."

2. Cardiovascular Health. Omega 3 fatty acids have also been proven to work wonders for your heart and the miles and miles of arteries and veins that make up your cardiovascular system. They help to lower cholesterol, tryglicerides, LDLs and blood pressure, while at the same time increasing good HDL cholesterol. This adds years to your life expectancy.

3. Protection from Stroke and Heart Attack. When plaque builds up on arterial walls and then breaks loose, it causes what's known as a thrombosis, which is a fancy way of saying clot. If a clot gets stuck in the brain, it causes a stroke and when it plugs an artery, it causes a heart attack. Research shows omega 3 fatty acids break up clots before they can cause any damage.

4. Better Brain Function and Higher Intelligence. Pregnant and nursing mothers can have a great impact on the intelligence and happiness of their babies by supplementing with fish oil. For adults, omega 3 improves memory, recall, reasoning and focus. You'll swear you're getting younger and smarter.

5. Less Depression and Psychosis. Making you smarter is not all omega 3 does for your brain. Psychiatry department researchers at the University of Sheffield, along with many other research studies, found that omega 3 fish oil supplements "alleviate" the symptoms of depression, bipolar and psychosis (Journal of Affective Disorder Vol. 48(2-3);149-55).

6. Lower Incidence of Childhood Disorders. Just to show how fish oil fatty acids leave nobody out, studies show that children (and adults) with ADD and ADHD experience a greatly improved quality of life. And those with dyslexia, dyspraxia and compulsive disorders have gotten a new lease on life thanks to omega 3 oils.

7. Reduction of Breast, Colon and Prostate Cancer. And finally, omega 3 fish oil has been shown to help prevent three of the most common forms of cancer – breast, colon and prostate. Science tells us that omega 3s accomplish this in three ways. They stop the alteration from a normal healthy cell to a cancerous mass, inhibiting unwanted cellular growth and causing apoptosis, or cellular death, of cancer cells.
LEE786
wow very good tips for fish oil.I agree with you.Thanks for sharing. tongue.gif

r4revolution
work on a biochemical pathway that reduces inflammation. Because so much of our food today enhances inflammation, there is evidence that many of our ailments like heart disease come from an overactive inflammatory response in the body.
John Bobbin BNat
Hi Anne Wilson,
I think you have jumped the gun big time here, the study you have mentioned will not be completed until August 2009, you posted this 15th June 2009, are you a fortune teller, can you look into the future or do you have access to other material you forgot to post a link to?

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Low-Fat Fish Oil Diet for Prostate Cancer Prevention
This study is currently recruiting participants.
Verified by University of California, Los Angeles, November 2008
First Received: November 25, 2008 Last Updated: December 2, 2008 History of Changes
Sponsors and Collaborators: University of California, Los Angeles
National Cancer Institute (NCI)
Information provided by: University of California, Los Angeles
ClinicalTrials.gov Identifier: NCT00798876
Purpose

Studies on patterns of how many men get prostate cancer in other countries show that environment contributes to the high incidence of prostate cancer in the United States. Epidemiology studies suggest that this influence may be reduced by the diet of men at risk of getting prostate cancer. Although the exact nature of the effects of diet are not completely known, the amount of fat eaten appears to affect the number of men who get prostate cancer. The type of fat also seems to matter. Eating more of a type of fat called omega-3 polyunsaturated fat is associated with decreased prostate cancer risk.

Omega-3 fat comes from fish and is quite different from the type of fat from animals and vegetables (omega-6 fat). Because the exact mechanism of this reduction in prostate cancer risk is not known, no blood test indications, called markers, have been discovered that would show the effect working.

Study doctors designed this study to try to find markers in the blood tests of men who have prostate cancer, and to find out if a diet supplemented with omega-3 type fat from fish oil helps reduce those markers, hence indicating that it helps reduce the cancer in these men. These men will be compared to men with prostate cancer whose diets do not contain the fish-oil fat.

The men chosen will have prostate cancer and be scheduled for operations to have their prostate glands removed. They will be chosen randomly to be given the fish-oil diet or a regular Western diet for comparison for 4 to 8 weeks. Their blood will be checked at the beginning of the diet. After the 4-to-8-week period, they will have their operations. Their blood will be checked again and a sample of their removed prostate will be examined to tell if the diet had any effect on the cancer and its markers.

Condition Intervention
Prostate Cancer
Dietary Supplement: Fish Oil
Dietary Supplement: Vitamin E supplement
Dietary Supplement: Western Diet
Dietary Supplement: Low-Fat Diet
Other: Medical Examination
Other: Dietary Interview
Other: Blood Draw
Procedure: Radical Prostatectomy

Study Type: Interventional
Study Design: Diagnostic, Randomized, Open Label, Placebo Control, Parallel Assignment, Pharmacokinetics/Dynamics Study
Official Title: Comparison Study of a Low-Fat Diet Supplemented With Fish Oil and a Standard Western Diet in Individuals With Prostate Cancer

Resource links provided by NLM:

MedlinePlus related topics: Cancer Dietary Supplements Diets Prostate Cancer
Drug Information available for: alpha-Tocopheryl acetate alpha-Tocopherol Vitamin E Tocopherols Tocotrienol Fish oil
U.S. FDA Resources

Further study details as provided by University of California, Los Angeles:

Primary Outcome Measures:

* To establish and validate intermediate biomarkers for prostate cancer prevention trials by conducting a dietary intervention trial of a low-fat diet with omega-3 fatty acid supplements in men undergoing radical prostatectomy. [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]


Secondary Outcome Measures:

* To establish and validate insulin growth factor-1 (IGF-1) and insulin growth factor binding proteins (IGFBP) as relevant intermediate biomarkers for prostate cancer prevention trials. [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
* To establish and validate serum and tissue fatty acids as relevant intermediate biomarkers for prostate cancer prevention trials. [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]


Estimated Enrollment: 70
Study Start Date: August 2005
Estimated Study Completion Date: August 2009
Estimated Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Standard Western Diet: Placebo Comparator

Subjects will be asked to consume a standard Western Diet for 4 weeks. For the 4-week period, subjects will be provided with all food and beverages.

Subjects will also undergo a medical examination, dietary interview, blood draw, and radical prostatectomy(as part of standard of care).
Dietary Supplement: Western Diet
Subjects will be provided with a standard western diet, food and beverages, to consume during their 4 week participation in this study.
Other: Medical Examination
Subjects will have a routine medical exam.
Other: Dietary Interview
Subjects will meet with the study nutritionist and have their current diet evaluated. Subjects will also undergo a test (bioimpedance) to estimate their body fat, lean weight, and the rate at which their body burns fat.
Other: Blood Draw
40 mL of blood will be drawn from subjects to measure PSA, fatty acids, insulin and various hormones.
Procedure: Radical Prostatectomy
Subjects will undergo a radical prostatectomy as part of their standard of care.
Low-Fat Diet: Experimental
Subjects will be asked to consume a low fat diet with fish oil and vitamin E supplements for 4 weeks. For the 4-week period, subjects will be provided with all food and beverages. Subjects will also undergo a medical examination, dietary interview, blood draw, and radical prostatectomy(as part of standard of care).
Dietary Supplement: Fish Oil
Subjects will be asked to take 10 grams of fish oil per day for 4 weeks.
Dietary Supplement: Vitamin E supplement
Subjects will be asked to take 800 International Units per day of Vitamin E for 4 weeks.
Dietary Supplement: Low-Fat Diet
Subjects will be provided with a low-fat diet (food and beverages) for their 4 week participation in this study.
Other: Medical Examination
Subjects will have a routine medical exam.
Other: Dietary Interview
Subjects will meet with the study nutritionist and have their current diet evaluated. Subjects will also undergo a test (bioimpedance) to estimate their body fat, lean weight, and the rate at which their body burns fat.
Other: Blood Draw
40 mL of blood will be drawn from subjects to measure PSA, fatty acids, insulin and various hormones.
Procedure: Radical Prostatectomy
Subjects will undergo a radical prostatectomy as part of their standard of care.

Detailed Description:

1. To establish and validate intermediate biomarkers for prostate cancer prevention trials by conducting a dietary intervention trial of a low-fat diet with omega-3 fatty acid supplements in men undergoing radical prostatectomy. In initial trials it was feasible to intervene with diet and obtain tissue and serum for bioassay and biomarker development. This aim is to study the effect a low-fat, high omega-3 diet has on serum and tissue biomarkers from patients who have prostatectomies for prostate cancer. Ultimately, we hope to identify and validate intermediate markers of efficacy for large-scale dietary prevention trials.
2. To establish and validate insulin growth factor-1 (IGF-1) and insulin growth factor binding proteins (IGFBP) as relevant intermediate biomarkers for prostate cancer prevention trials. IGF-1 is a peptide growth factor that is important to the growth and progression of prostate cancer. To our knowledge, no prospective dietary intervention studies have evaluated the effect of a low-fat diet with omega-3 fatty acid supplements on IGF-1 and IGFBPs, and their potential to serve as relevant intermediate markers for low-fat dietary intervention trials for prostate cancer prevention.
3. To establish and validate serum and tissue fatty acids as relevant intermediate biomarkers for prostate cancer prevention trials. We will evaluate if men randomized to a low-fat, fish-oil-supplemented diet have increased serum ratios of omega-3:omega-6 fatty acids compared with men randomized to a control Western diet before radical prostatectomy. We also will study if patients in the low-fat, fish oil arm have increased ratios of membrane omega-3:omega-6 fatty acids as well as decreased COX-2 and decreased PGE-2 levels in benign and malignant tissue and in visceral fat. If so, it will proved further evidence to support the potential of low-fat fish oil diets for prostate cancer prevention. If serum omega-3:omega-6 ratios correlate with changes in COX-2 and PGE-2 in tissues, then serum omea-3:omega-6 ratios may be useful for monitoring activity and efficacy of low-fat fish-oil-supplemented diets in future trials.

Eligibility

Ages Eligible for Study: 40 Years to 75 Years
Genders Eligible for Study: Male
Accepts Healthy Volunteers: No
Criteria

Eligibility Criteria:

* Patient consents to participate.
* Medically able to receive and comply with the diet.
* Lives near enough for counseling and follow-up.
* Has elected to have operation to remove prostate.
* Agrees to stop diet or vitamin supplements or herbal supplements for 1 week before the study begins.
* Patient able to stop taking aspirin, COX-2 inhibitors, and other anti-inflammatory medications for 1 week before study start.
* Patient able to safely stop taking fish oil capsules 2 weeks before the diet starts.

Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00798876

Contacts
Contact: William Aronson, M.D. 310-268-3446 waronson@ucla.edu

Locations
United States, California
UCLA Jonsson Comprehensive Cancer Center Recruiting
Los Angeles, California, United States, 90095
Contact: William Aronson, MD 310-268-3446 waronson@ucla.edu
Sub-Investigator: John Glaspy, MD
Sub-Investigator: Pinchas Cohen, MD
West Los Angeles VA Recruiting
Los Angeles, California, United States, 90073
Contact: William Aronson, MD 310-268-3446 waronson@ucla.edu
Sponsors and Collaborators
University of California, Los Angeles
National Cancer Institute (NCI)
Investigators
Principal Investigator: William Aronson, MD UCLA and Western Los Angles VA
More Information

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Responsible Party: UCLA ( William Aronson, MD )
Study ID Numbers: 01-07-026, P50 CA 92131-01A1
Study First Received: November 25, 2008
Last Updated: December 2, 2008
ClinicalTrials.gov Identifier: NCT00798876 History of Changes
Health Authority: United States: Institutional Review Board

Study placed in the following topic categories:
Tocopherol acetate
Antioxidants
Genital Neoplasms, Male
Prostatic Diseases
Tocopherol
Trace Elements
Urogenital Neoplasms
Genital Diseases, Male
Hormones
Insulin
Alpha-Tocopherol
Tocopherols
Vitamin E
Tocotrienol
Vitamins
Tocotrienols
Micronutrients
Prostatic Neoplasms

Additional relevant MeSH terms:
Antioxidants
Genital Neoplasms, Male
Prostatic Diseases
Molecular Mechanisms of Pharmacological Action
Growth Substances
Physiological Effects of Drugs
Urogenital Neoplasms
Genital Diseases, Male
Protective Agents
Pharmacologic Actions
Neoplasms
Vitamin E
Neoplasms by Site
Vitamins
Micronutrients
Prostatic Neoplasms

ClinicalTrials.gov processed this record on July 21, 2009




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Cheers biggrin.gif biggrin.gif biggrin.gif biggrin.gif
cathyz
Fish Oil has numerous health benefits in human body and the most well known health benefits of fish oil is the source of omega-3 which promote antioxidant, for strong immune and nervous system. That is why most of the natural health products from fish oil are been one of the best to buy from now a days.
John Bobbin BNat
Hi Charles Martin,

People will go to extremes to get their fish oil mate.

http://mail.google.com/mail/?account_id=jo...amp;disp=inline

Seriously I agree that fish is great but because you Americans are so unscientific about your arguments a lot of the health benefits you guys attribute to fish oil, and indeed everything else, has not been proven yet. Hype is not proof, it is just selling technique, and you guys fall for it every time. Look at the lady earlier in this post that quoted all of these benefits from a study that hasn't even finished yet, and this type attitude is the prevailing attitude on here.

Everyone makes mistakes, I have made thousands, and some of them by jumping the gun, the very thing I am critical of here, but I didn't do it often, not like you see on here where it is done about everything every day, and a lot of the people do not learn from their mistakes, they make the same mistake daily, they must have been terrible students at school. Health is a subject we should all try to master for our families sake, we don't want to give them bad advice for it may come back to haunt us.

Did you see the book that appeared on New Scientist this week entitled "Unscientific America" they have got a case mate.


Cheers biggrin.gif biggrin.gif biggrin.gif biggrin.gif
John Bobbin BNat
Hi Shane,
I think you are pretty right here mate, cold water fish have the highest level of omega 3 fatty acids, and that puts sardines, mackerel and atlantic salmon, as well as red salmon from up north at the top of the range, I didn't think albacore was that high I always found it pretty dry when we were canning it, Americans call it chicken of the sea because it is so white and they always can it with spring water, or at least that is the way the did it in the 70's - 80's.

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alexa
Fish Liver oil contains mainly fat but it contains many micro nutrients... It is a huge sourse of fat soluble Vitamines such as Vitamines A,D,E,K... Mainly Vit.A & Vit. E. I think no need 2 explain the uses of these vitamines.. U might be already knoing it..
Acne Treatment
Your thread is really very nice and interesting,i like it.
melisadenny
Thanks for your useful information.Not only that, but you can also get better skin health from fish oil. It has nutrients that will turn your dry, irritated skin into shiny, glowing skin. You may be suffering from a skin disease like eczema, lesions, or rashes, and it can help treat them. If you have psoriasis, you are able to use it topically to relieve the symptoms. Even if you don’t have any abnormal skin condition, regular use will still leave you with more moisture in your skin, making you look both healthier and younger. That can’t be a bad thing.
John Bobbin BNat
Hi Guys,

Vitamin A can have toxic effects for pregnant women in large doses, are you confident when you prescribe vitamin A or just following guidelines set down by some manufacturer. Any fat soluble vitamin can accumulate in fatty tissue to dangerous levels.

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livehealthy
As Fish oil contains contains Omega 3 oils, it is very effective in treating skin problems especially eczema.
niki
Thank you for the article. Full article can be found at;

http://ezinearticles.com/?7-Fish-Oil-Benef...h&id=415032
John Bobbin BNat
Hi niki,
Why would you refer readers to that website, Homer Simpson could write those articles and they would have the same amount of credibility, look at the guidelines for people wanting to submit articles, scientific studies does not get mentioned, you understand this don't you.

Try this analogy.... You are accused of doing something illegal, you go to court, the prosecutor starts to invent stories about what you have done for the jury...... wouldn't you prefer that he ( the prosecutor) was made to only tell the truth, and prove that he was telling the truth?
Look at this

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Now I ask you wouldn't you have a lot more confidence in an article that was published in PubMed.... that had been checked by experts doing research in the same field (peer reviewed), I know I would.

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Successfulgirl
I read sometime back that fish Oil has numerous health benefits in human body and the most well known health benefits of fish oil is the source of omega-3.

HealthCastle Staff
Hello Successfulgirl
The topic sure changed course . . .
You may like to check out this article titled 'Health Benefits of Omega 3 Fatty Acids':
http://www.healthcastle.com/omega3.shtml
Enjoy the read,
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