Hi all members of Health Castle forum

Now , new thread are opened for public .
This thread is talking about everything related to "anti aging world" .
You'll see new article bout anti aging every week .
Please give me your comment or opinion bout the article .

Regards,
Cmichael



Mechanisms of translational control in aging liver
Posted in Aging on Wed October 04, 2006

Gene expression changes dramatically over the course of aging. It’s relatively common to find a paper that addresses these alterations in gene expression (especially at the level of transcriptional regulation), but rare to find one that addresses the mechanism of the change. Which factors govern differential gene expression in the aged cell? We don’t know, and in the age of cheaper and cheaper microarrays and increasingly accessible mass-spec for protein expression studies, it seems like we rarely ask.

Hence I was pleased to see today’s paper. Timchenko et al. begin with a few established points of reference (known changes in gene expression and in levels of regulatory proteins) and proceed to systematically identify and characterize a multiprotein complex, involved in translational regulation, that is upregulated in the aged liver. Furthermore, they demonstrate that this complex determines differential translation of multiple isoforms of a broad-spectrum transcription factor:

RNA binding protein, CUGBP1, regulates translation of proteins in a variety of biological processes. In this paper, we show that aging liver increases CUGBP1 translational activities by an induction of a high molecular weight protein-protein complex of CUGBP1. The complex contains CUGBP1, subunits alpha, beta and gamma of the initiation translation factor eIF2 and four proteins of the endoplasmic reticulum, eR90, CRT, eR60 and Grp78. The induction of the CUGBP1-eIF2 complex in old livers is associated with the elevation of protein levels of CUGBP1 and with the hyper-phosphorylation of CUGBP1 by a cyclin D3-cdk4 kinase, activity of which is increased with age. … The CUGBP1-eIF2 complex is bound to C/EBP beta mRNA in the liver of old animals and this binding correlates with the increased amounts of LAP and LIP. Consistent with these observations, the purified CUGBP1-eIF2 complex binds to the 5’ region of C/EBP beta mRNA and significantly increases translation of the three isoforms of C/EBP beta in a cell-free translation system, in cultured cells and in the liver. Thus, these studies demonstrated that age-mediated induction of the CUGBP1-eIF2 complex changes translation of C/EBP beta in old livers.

CUGBP-1 was already known to be upregulated in senescent fibroblasts, where it increases translation of CDK inhibitor p21WAF1. LIP, the C/EBPß isoform whose levels rise, was already known to be upregulated in the aging liver. The novelty here is in mechanistically bridging the two observations, showing that both in vivo and in vitro, the upregulation of a multiprotein complex containing CUGBP-1 increases translation of this specific C/EBPß isoform.

LIP is a dominant negative whose expression presumably represses transcription of genes responsive to other C/EBPß isoforms; while the full ramifications of the upregulation of LIP await a detailed transcriptional study, but it’s reasonable to speculate that high LIP results in repression of liver-specific genes in an aged organ.

So I like this prelimiary story: A multiprotein complex specific to an aged tissue post-transcriptionally regulates a transcription factor, resulting (presumably) in a dramatic change in transcription throughout the genome. Granted that in one sense it simply pushes the question back one step further (why the upregulation of the CUGBP-1 complex?), it still provides refreshing dose of mechanism in a line of research that sometimes gets bogged down in the lepidopteristic listing of upregulated and downregulated genes.

One point of disgruntlement: The authors used mass spec to identify the subunits of their complex, and confirmed the identifications by Western blot. Strangley, several of the proteins (CUGBP-1 and the subunits of eIF2) are cytosolic — but several others (including Grp78 and calreticulin) live in the endoplasmic reticulum (ER). Now, the cytosol and the ER are separated by a membrane that takes some work to get across, so it’s hard to believe that the native complex actually includes all of these proteins. I would hazard to guess that the cell lysis conditions used here somehow violate the ER membrane and allow abundant chaperones to bind to the cytosolic “half” of the complex. The authors are curiously uncritical about their discovery of a multiprotein complex whose subunits reside in different membrane-bound compartments of the cell, failing to mention this issue even in passing.

Finally, a more general point on the study of gene expression in aging. A question unasked and therefore unanswered in this and many papers is what, if anything, age-related changes in gene expression signify: Are they deleterious, protective, passive responses to damage-induced signals, neutral, or other? It’s a gigantic question, far beyond the scope of any one paper. But since I introduced the discussion of the paper by talking about what I’d like to see more of in the field, it seems an appropriate way to end.

Happy Friday, everyone. Be good to your livers.

http://www.worldhealth.net/news/mechanisms...al_control_in_a





Obama White House Can Save $3.7 Trillion and Extend Lifespan 29+ Years,
Predicts Revolutionary A4M Healthcare Plan

Contributing Editors
Ronald M. Klatz, M.D., D.O., President & Physician Co-Founder, American Academy of Anti-Aging Medicine (A4M); Appointed member, Global Action Council on the Challenges of Gerontology, World Economic Forum; Director, World Anti-Aging Academy of Medicine
Robert M. Goldman, M.D., Ph.D., D.O., FAASP, Chairman & Physician Co-Founder, American Academy of Anti-Aging Medicine (A4M); World Chairman, International Medical Commission; Chairman, World Anti-Aging Academy of Medicine; President Emeritis, National Academy of Sports Medicine
Joseph C. Maroon, M.D., Professor of Neurosurgery, Heindl Scholar in Neuroscience and Vice Chairman of Neurosurgery, University of Pittsburgh Medical Center; Member of the International Editorial Board, Neurological Research and the Journal of Sports Medicine; Past President, Congress of Neurological Surgeons
Nicholas A. DiNubile, M.D., Orthopaedic Consultant to the Philadelphia 76ers Basketball Team and Pennsylvania Ballet
Michael Klentze, M.D., Ph.D., Secretary-General, European Society of Anti-Aging Medicine; Medical Director, Vitalife Wellness Center of Bumrungrad Hospital, Thailand


The American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net), the world's largest professional organization dedicated to advancing research and clinical pursuits that enhance the quality, and extend the quantity, of the human lifespan. unveils an innovative, technology-based fix to healthcare with the potential to:
• Increase the lifespan, or improve the healthspan, of all Americans by 29+ years;
• Slash healthcare costs, saving $3.7 Trillion; and
• Replace the disease-based approach to medicine with a wellness-oriented model

A comprehensive program to reform and advance healthcare in the United States, The A4M Twelve-Point Actionable Healthcare Plan: A Blueprint for A Low Cost, High Yield Wellness Model of Healthcare by 2012 has garnered support from 35 professional medical organizations and educational institutions and was developed with invaluable input from the 24,000 physician, health practitioner, and scientist members of the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net) who represent 110 nations worldwide.

When legislators on Capitol Hill return for the Fall Congress Session, they will continue to debate a $1.65 trillion, 10-year plan to overhaul the nation’s failing healthcare system. The majority of the plan focuses on how to pay for health insurance, rather than formulating a comprehensive plan of action for reform itself. The contributing editors, authors and endorsing organizations of The Twelve-Point Plan submit that the underlying philosophy of healthcare in this nation must be reformed in revolutionary new ways. In place of the disease-based approach that treats people after they exhibit signs of illness, we submit that it is time for the nation to adopt a wellness-oriented model to healthcare. Such a model stresses very early detection of illness and promotes disease prevention, yielding opportunities for the best prognoses and economical treatments. As reported by the Congressional Budget Office, up to one-third of this nation’s healthcare spending -- more than $700 billion -- does not improve Americans' health outcomes.


To compound the issue of healthcare reform, the United States is a driving force in a trend of unprecedented global aging. The average age of the world's population is increasing at an unprecedented rate. The number of people worldwide ages 65+ was 506 million as of midyear 2008; by 2040, that number will hit 1.3 billion. Thus, in just over 30 years, the proportion of older people will double from 7% to 14% of the total world population. In the United States, men and women ages 65+ represented 12.4% of the population in the year 2000, with that age bracket projected to swell to stand at 20% of the population by 2030. In 2007 in the United States, six major diseases among Americans ages 65+ resulted in medical and lost productivity costs of more than $196 billion. In the coming years, the cases of these six diseases, namely -- chronic lung disease, ischemic heart disease, stroke, lung cancer, pneumonia and gastrointestinal illness -- are expected to surge as the population ages, potentially sending the costs of age-related diseases skyrocketing. Steps to prepare the nation to address the social, economic, and personal ramifications of a graying society now, are urgently necessary.

Anti-aging medicine is the pinnacle of biotechnology joined with advanced clinical preventive medicine. Adoption of the anti-aging medical model delivers the best of advanced preventive medicine to all Americans, not merely our older population segments. The contributing editors, authors and endorsing organizations of The Twelve-Point Plan urge this nation to adopt a wellness-oriented model to healthcare.

The elements of The Twelve-Point Plan will significantly improve and extend the healthy human lifespan. Each of the points of this Program will also deliver a profound net economic savings via three major mechanisms:
1. Conservation of worker productivity
2. Reduction of disability and hospitalization costs
3. Reduction of the burden of costs associated with chronic long-term medical conditions.

The Twelve-Point Plan provides practicable “here and now” solutions to reform and advance healthcare in the United States, while addressing the challenges of global aging. Indeed, the implementation of The A4M Twelve-Point Actionable Healthcare Plan: A Blueprint for A Low Cost, High Yield Wellness Model of Healthcare by 2012 may save our society a projected $3.64 Trillion in healthcare costs, and extend the healthy lifespan of each of our nation’s residents by up to 29 productive, vital years.

Complete references and supporting data for projections may be viewed in the full version of The A4M Twelve-Point Actionable Healthcare Plan: A Blueprint for A Low Cost, High Yield Wellness Model of Healthcare by 2012. Request your free copy of this White Paper, at: www.waaam.org/twelve_points_summary.php.

for more information , visit here :
http://www.worldhealth.net

The Female Sex Hormones: Extrogen and Progesterone, Chapter Six


How Estrogen Fights Aging

Proponents of estrogen cite both scientific studies and the experiences of numerous women to show that this female hormone can ease or eliminate menopausal woes. Estrogen supplements, which are available as skin patches, topical creams, and long-lasting injections, appear to relieve hot flashes, night sweats, and other discomforts, as well as vaginal dryness and atrophy. Some women find that this hormone helps keep their skin thicker, moister, and more youthful-looking.

Collagen, which is stimulated by estrogen, is the main protein in the dermis. A loss of collagen results in increased wrinkling, bruising, and thinning of the skin. Administering estrogen not only prevents collagen loss but also increases collagen synthesis, which can relieve symptoms of diminished urinary control sometimes experienced by menopausal women. Estrogen moistens the vaginal mucous membranes, which increases lubrication, and also helps maintain flexibility of the connective tissues.

Estrogen and progesterone supplements have also been proven to reduce the bone loss associated with osteoporosis. Women’s bones slowly begin to lose minerals and become less dense even before menopause. After menopause, however, the pace accelerates rapidly for five to ten years. Estrogen inhibits bone re-absorption and progesterone stimulates bone formation. Unless a woman is taking these hormones, she has about a one-in-four chance of developing serious osteoporosis.

Osteoporosis increases the risk of bone fractures and all their ensuing complications. One study found that older women who took estrogen were subject to only half the number of bone fractures as those women who avoided the hormone supplement.

A recent analysis by the Postmenopausal Estrogen and Progestin Intervention Trial revealed that estrogen alone and in various combinations with progesterone is equally effective in increasing bone mass in postmenopausal women. Data found that fewer than 3 percent of women on estrogen therapy continued to lose a clinically relevant and measurable fraction of bone density at the spine.

By age seventy, almost 50 percent of women have had at least one osteoporotic fracture, at an estimated cost of $17 billion annually in the United States. A menopause symposium sponsored by the Oregon Health Sciences University School of Medicine concluded that estrogen is the therapy of choice for prevention and treatment of osteoporosis. Although supplemental calcium, diet, and exercise are also beneficial, they don’t seem to be as effective as estrogen.

The most important benefit of estrogen replacement therapy is the reported reduction in coronary artery disease - the leading cause of death in post-menopausal women. Some 500,000 women die from coronary artery disease per year - that’s twice as many women as those who die each year from cancer. Apparently, the high premenopausal levels of estrogen tend to protect women from heart disease, partly by keeping levels of HDL cholesterol high and LDL cholesterol low.

Without estrogen replacement, a woman’s risk of heart attack becomes equal to a man’s within fifteen years after menopause. Simply being postmenopausal puts a woman at a higher risk for heart disease, and having just one additional risk factor - smoking, high blood pressure, HDL cholesterol below 35 mg/dl, diabetes, or a family history of heart disease - puts her at an even higher risk. With estrogen, however, the blood vessels dilate slightly, cholesterol balance is maintained, and the risk of heart disease vastly decreases. This can be seen in a report from a ten-year study of some 48,470 nurses from the Nurses Health

Study (National Health and Nutrition Examination Survey, or NHANES) - one of the largest studies to date - which found that estrogen use reduced the risk of major coronary disease and fatal cardiovascular disease by half.

Dr. Lawrence Brass of Yale University School of Medicine predicts that ERT may soon emerge as one of the most effective therapies for stroke prevention, cutting the risk of stroke in postmenopausal women in half. He believes that because estrogen prevents heart disease by 50 to 70 percent, it may also "plausibly" prevent stroke.

In a Leisure World prospective cohort study, estrogen therapy was associated with a 46 percent overall reduction in the risk of death from stroke, with a 70 percent reduction in recent users. This protection was present in women both with and without hypertension and in both smokers and nonsmokers. In addition, a population-based cohort study in Uppsala, Sweden, documented a 30 percent reduced incidence of stroke in postmenopausal users of estrogen, as well as in women given an estrogen-progestin combination.

However, a large cohort from the Nurses’ Health Study produced results in striking contrast, failing to show a protective effect of estrogen against stroke. However, critics have pointed to the fact that the women in the study were too young, where there was little protective effect against stroke.

Although estrogen is primarily a female hormone, men also produce it. In fact, estrogen levels in men can be higher than in postmenopausal women.

In addition to reducing the risk of cardiovascular disease and osteoporosis, postmenopausal hormone replacement therapy may allow more women to retain their teeth as they age. By preventing osteoporosis, estrogen may add the benefit of preventing tooth loss and the need for dentures in older women. A new study of 3,921 women found that those on hormone replacement were 19 percent less likely to have some tooth loss and 36 percent less likely to have no teeth than women who had never taken hormones. Researchers also suggest that because tooth loss provides a measure of skeletal bone health, it may be the first clinical sign of osteoporosis.

Estrogen also seems to reduce the risk of colon cancer - and the longer a woman takes estrogen, the lower her risk. New research has found that estrogen users had a 29 percent lower risk of dying from colon cancer than non-users; risk for users of ten years or more was 55 percent lower.

The North American Menopause Society suggests that the addition of a low-dose testosterone to oral estrogen therapy may be more effective than estrogen alone in diminishing symptoms of menopause in older women. Hot flashes and vaginal dryness seem to improve, and most significantly, fatigue, insomnia, irritability, and nervousness are relieved.

In order to get the positive benefits of ERT, doctors believe that it should be taken for at least seven years, although a full 95 percent of the women engaged in hormone replacement therapy continue for only three years or less. According to Dr. John Gallagher, an endocrinologist at Creighton University in Omaha, Nebraska, three years is "not long enough to get any positive effects on their bones."

Menopause

An estimated 40 million American women are in or past menopause, with another 20 million due to reach menopause within the next decade. With the increase in life expectancy, many women will be spending one-third or more of their lives in postmenopausal years. Menopause by definition begins after the last spontaneous menstrual period.

Once a woman has gone from six to twelve months without a period, she is considered to have reached menopause. In the United States, the average age for menopause is fifty, although considerable variation certainly exists.

Many people tend to associate menopause with a host of psychological problems, particularly depression, loss of energy, and crying episodes. It isn’t clear what amount of these reactions stems from hormonal changes and what may be due to negative images of older women. In any case, many women experience renewed zest and vigor after menopause. Anthropologist Margaret Mead called this period "postmenopausal zest", while author Gail Sheehy commented that postmenopausal women feel "a greater sense of well-being than any other stage of their lives."

Studies show that women who predict that menopause will be miserable do, in fact, suffer more negative emotional and physical symptoms than women who expect it to be easier.

Hot Flashes

Some 85 percent of all women do experience hot flashes, either during peri-menopause or in menopause itself. The physiology of the hot flash is still not understood, but it appears to start in the hypothalamus, "the body’s thermostat," in response to a drop in estrogen. During a flash, a woman experiences a severe feeling of heat, especially in the head and neck, often in the entire upper half of the body. Sometimes the face is blotched and ruddy as a result of the dilation of blood vessels on the surface of the skin. In some cases, flashes are accompanied by disruptions in sleep patterns and night sweats.

In the Massachusetts Women’s Health Study, the incidence of hot flashes rose from about 10 percent during the perimenopausal stage to about 50 percent just after cessation of menses, and dropped back to about 20 percent four years after menopause.

Flashes usually last for only a few minutes, but may continue for up to an hour. The body will attempt to cool down by beading with perspiration. Hot weather, hot food or drink, stress, and other sources of heat can trigger flashes without warning. Although most women experience them, few - only one in four - find them uncomfortable enough to seek treatment.

Some studies have shown that as little as 15 to 30 IU of vitamin E daily helps ease hot flashes and vaginal dryness, prevents hysterectomy, and in some cases, eliminates the need for estrogen replacement.

Many women who seek estrogen treatment for their hot flashes do find relief. Yet in all cases, whether treated or not, they will eventually stop as soon as the body adjusts to postmenopausal levels of estrogen.

Lower Sex Drive

Another key symptom of menopause is the atrophy of the reproductive tract. Estrogen, produced by the ovaries, keeps the uterus, vagina, and base of the bladder moist and supple. When estrogen levels start to fall, these organs start to shrink, and the vaginal walls thin. Generally, blood flow to the area decreases, as does lubrication. Women may have difficulty controlling their bladders under stress, and they’re more likely to suffer from vaginal itching, dryness, and sometimes pain during or after intercourse. As a result, some women become less interested in sex. Other women may experience a loss in libido even without these symptoms.

http://www.worldhealth.net/pages/the_femal...xtrogen_and_pro

for more information , visit here :
http://www.worldhealth.net

Dipping into the fountain of youth, AMNews


Dipping into the fountain of youth.
The promise of eternal life and endless youth appeals to patients and doctors alike. But is anti-aging medicine offering elixir or poison?
By Deborah L. Shelton, AMNews staff. Dec. 4, 2000.

Some doctors say science has discovered what Spanish explorer Juan Ponce de León never could: the fountain of youth. And for people who want to take a sip -- or in some cases, to dive right in -- there are now plenty of places to seek eternal youth without having to embark on an exhaustive search. In recent years, hundreds of anti-aging clinics have sprouted up across the country with the tantalizing promise of enabling people to live decades longer and healthier.

The concept appeals to many doctors. About 2,500 physicians nationwide have established specialty practices in longevity medicine over the past 10 years, according to the American Academy of Anti-Aging Medicine, a Chicago-based organization of 10,000 physicians and scientists. Broadly defined, anti-aging medicine involves the use of any technique, technology, medication or intervention for early detection, prevention, treatment or reversal of age-related disease. "The demographic is the largest in medicine," says academy president and founder Ronald O. Klatz, MD, DO. "We offer something for everyone age 45 and older. Once you start the process of aging, anti-aging medicine has something for you."

Some doctors have turned to anti-aging medicine as patients. "The results are remarkable," says Donald Kozil, MD, a 68-year-old suburban Chicago ophthalmologist, who has been taking human growth hormone and vitamin supplements as part of an anti-aging program since August 1999. "I'm not saying I'll live one day longer than the good Lord intended, but I want to be as healthy as I can for the time I'm here," he said.

Anti-aging physicians fall into one of two camps: those working to extend life span -- particularly "health span," or years of healthy living -- and those who believe that people can achieve immortality.

"Immortality is within our grasp," proclaims a recent news release from the academy, the only medical society dedicated to the science and practice of longevity medicine.

One of the goals of the anti-aging organization is to refute the view that aging is natural. "Our motto is: 'Aging is not inevitable,' " Dr. Klatz said. "There are effective treatments and interventions for memory loss, visual impairment, slowed gait and speech, wrinkling of the skin, hardening of the arteries and many of the maladies we call aging."

Advances in medicine and public health dramatically increased life expectancy during the 20th century. Vaccinations, antibiotics, improvements in sanitation and nutrition, and treatments for heart disease and cancer, among other things, have all contributed to a rise in life expectancy in the United States. At the turn of the century, people lived 47 years, on average. Today, average life expectancy is 77 years, a historic high.

The once exclusive centenarian club has become increasingly crowded. An estimated 100,000 Americans are age 100 or older, a number that has tripled in the past 20 years. Many anti-aging doctors and scientists believe that living at least 100 to 120 years will soon be the norm. "We have learned so much in the past 50 to 60 years about the biology of aging that it is now possible to envision the development of interventions that could retard aging and aging-related diseases in humans," said Mark A.

Lane, PhD, chief of the nutritional and molecular physiology unit in the laboratory of neurosciences at the National Institute on Aging. However, the demography of aging -- with the over-65 age group expected to explode from 4% to 13% of the population over the next 10 years -- also opens the door to "new markets for snake oil salesmen," said Dr. Lane, who's also president of the American Aging Assn.

The science
New scientific findings are bolstering the idea that the afflictions of old age may one day be successfully treated. Earlier this year, scientists at the University of Illinois at Chicago discovered that a single gene, p21, might be responsible for conditions ranging from heart disease to Alzheimer's disease.

A team of scientists at Scripps Research Institute in La Jolla, Calif., reported last spring that genes critical to cell division could be the cause of age-related body changes, such as graying hair.

Anti-aging scientists and doctors are also looking to the Human Genome Project for discoveries that could lead to new interventions to prevent, retard or reverse aging.

"There may be 50 to 75 'gerontic' or 'youth genes' in humans that determine one's capacity to modify the factors that determine maximum life span," said Karlis Ullis, MD, an anti-aging doctor in Santa Monica, Calif. "A good example of that was shown in the studies of the Caenorhabditis elegans worm. A few genes were altered and the worm vastly outlived the nonaltered worm and looked very vigorous, even at an advanced age." There is a split in the anti-aging scientific community about what to do with some research findings. Clinicians have been eager to apply various antiaging interventions. Basic scientists have tended to think that many of those interventions haven't been sufficiently studied.

Intervening in the aging process is not a new concept. Scientists have been researching the idea since the 1930s, most notably in studying the effects of caloric restriction. Hundreds of studies with rodents have demonstrated that reducing food intake by 30% to 50% can dramatically extend life span. Work with primates over the past 10 years suggests that caloric restriction has the potential to retard aging and extend life in humans as well. "If we can ascertain the mechanisms involved, we can come up with mechanisms that work in humans," said Dr. Lane, who conducts research in this area of anti-aging.

But the science is far less clear when it comes to widespread use of herbal medicines, dietary supplements and hormone replacement therapies -- the foundation of the type of anti-aging medicine typically practiced today. "Some of it is quackery," Dr. Lane said. "That is the stigma -- and the challenge -- that anti-aging medicine faces over the next few years."

The practice
Anti-aging doctors say they perform extensive evaluations of a person's health and "biomarkers" before designing individualized treatment. Part of the workup involves determining biological age, as opposed to chronological age.

For $1,750, Alan P. Mintz, MD, puts his patients through a battery of blood tests and completes detailed histories that look at mental health, nutrition, exercise and other lifestyle issues. Patients also undergo cognitive testing, agility testing and strength testing. Some screenings create a baseline to measure progress; others are used to determine which conditions can be treated hormonally.

Blood levels are monitored quarterly, and patients -- some of whom fly in from other states or overseas -- return at least once a year for follow-up. The goal of treatment is to "stay as close to the physiology of a 30-year-old as possible," said Dr. Mintz, chief medical officer and CEO of Cenegenics, based in Las Vegas.

Replacement therapies for estrogen, testosterone and human growth hormone play a major role. Human growth hormone, produced in the pituitary gland, is responsible for a wide range of youthful attributes, such as increased muscle and bone mass, decreased body fat, strengthening of the immune system and a greater sense of well-being and energy. Testosterone can improve mood, alertness, libido, and skin and muscle tone in both men and women. For most people, hGH levels drop dramatically by age 30. Testosterone levels also decline.

"Testosterone and natural estrogen and natural progesterone, when used correctly and safely, are cornerstones of anti-aging therapies," said Dr. Ullis.

He has treated more than 500 patients with hGH but now believes "it's not the wonder drug that the public has been led to believe." Other methods can work as well, such as intense weight training, caloric restriction, moderate cardiovascular workouts, moderately high protein intake, deep sleep and positive social relationships, he said.

Some doctors have raised concerns about the widespread use of hGH because it stimulates the liver to increase production of the insulin-like growth factor, which normally declines with advancing age. Samuel S. Epstein, MD, professor of environmental medicine at the University of Illinois School of Public Health in Chicago, has warned fellow doctors of the potential dangers of widespread use, which include increased risks of colon, prostate and breast cancers.

"For these reasons, anti-aging hGH medication, compounded by failure to explicitly disclose its grave risks, constitutes medical malpractice," Dr. Epstein said in a statement in September.

Studies have found that when used to treat patients, testosterone can cause fluid retention, stimulate aggressive behavior and raise red blood cell counts.

Both hormones are indicated only for actual deficiency, said Paul S. Jellinger, MD, president of the American Assn. of Clinical Endocrinologists.

The issue gets complicated in the context of anti-aging medicine. Does natural decline usually suggest the need for treatment? "The biggest problem in this field is to separate those people with true deficiency and those with normal declines that come with aging," Dr. Jellinger said. "There is no strong evidence that everyone who has the normal decline of testosterone from aging is a candidate for replacement therapy." Nearly nine of 10 endocrinologists polled in a recent survey said they were concerned that increased availability of testosterone replacement therapies, combined with widespread publicity about potential benefits, could lead to inappropriate prescribing by doctors and serious health consequences for male patients.Questions about the safety and validity of hormone replacement underscore the uncertainties about anti-aging medicine.

"Some doctors think they can take a weekend seminar and become a specialist in anti-aging medicine," said Dr. Ullis, who has been practicing it for about 10 years. "You can't learn endocrinology and exercise physiology over a weekend. Patients are asking about supplements and hormones, and doctors have to be well-informed."

Fountains of youth
Examples of some potential anti-aging treatments include the following:
l Stem cell therapies.
l Bionic organ parts.
l Designer anti-aging diets.
l Microscopic "robots" injected into the bloodstream to detect and repair problems at the tissue and cellular levels.
l Genetic engineering using retroviral or liposomal vectors for the delivery of human artificial chromosomes.
l Delivery of medications and natural hormones, using implantable pumps.
l Experimental investigations utilizing cells from bacterial colonies, yeast, nematodes, fruit flies, rodents, bats, rabbits and monkeys.

Fighting Mother Nature and Father Time
If you build it, they will come. If you promise eternal youth, they will stampede.

Who are these people who seek out anti-aging medicine? "I like to call my patients 'health and wellness optimizers,' " said Karlis Ullis, MD, an anti-aging physician in Santa Monica, Calif. "They want the most and best out of their lives."

Patients in Dr. Ullis' practice are more likely to be men than women. The average age is 40 to 50. They tend to be successful in their careers. Dr. Ullis describes the average patient as a "well-educated, successful, strongwilled and disciplined individual." But there is a tendency to go to extremes. "I have to tell them that filling up their bodies with high-octane hormones will not automatically make their old Chevy bodies into sleek Ferrari race cars," he said.

Alan P. Mintz, MD, who operates a multioffice anti-aging practice in Las Vegas, said patients come to him for four reasons: the desire to maintain memory function; to increase energy, especially sexually; to develop a strong immune system; and for vanity.

"The goal of most people who come to me is to maintain a very high standard of life; 60% to 70% are healthy," he said. The remainder have chronic health problems such as asthma, diabetes, neurologic disorders or chronic fatigue.

"They don't want to take aging lying down," said Ronald O. Klatz, MD, DO, president of the American Academy of Anti-Aging Medicine, who has a practice in Chicago. "They believe -- and I agree -- that they can avoid Alzheimer's disease, osteoarthritis, fatal heart attack and stroke. The technology is there to accomplish all of these things. It's merely an application of existing technology, which traditional medicine has ignored." Ultimately, anti-aging medicine seeks to create "an ageless society where you can't distinguish with the naked eye between an average 65-year-old and a healthy and athletic 105-year-old, and we're seeing that right now," Dr. Klatz said. "Look at some of the older athletes and Hollywood stars. People in their 80s are fit and vital and look great."

Weblink
National Institute on Aging Research Programs page (http://www.nih.gov/nia/research/)

American Federation for Aging Research (http://www.infoaging.org/)

American Academy of Anti-Aging Medicine (http://www.worldhealth.net/)
Gerontology Research Group (http://www.grg.org/)

for more information , visit here :
http://www.worldhealth.net

wow , thx for update info
don't mind to share it again

Asian women in Bergen have nation's top life expectancy

Even the leader of a new Harvard University study on longevity was surprised to find that Asian-American women living in Bergen County have the longest life expectancy in the nation, typically reaching age 91. "Yes, it's surprising and interesting," said Dr. Christopher Murray, a population health specialist at the Harvard School of Public Health. "I was very surprised that it was Bergen County, as opposed to Asian-American women living in a whole series of well-to-do counties in California," Murray said in a phone interview Monday. More surprising, Murray found, were the stark health disparities in the nation that make the United States seem more like what he calls "eight Americas" instead of one. The initial results of his government-funded study were reported this week in the online science journal PLoS Medicine. The Asian women in Bergen, for example, lived an average of 33 years longer than American Indian men in parts of South Dakota, who die around age 58, the study found.

New Jersey, where life expectancy is 77.5 years, ranks 23rd- highest among the 50 states and Washington, D.C. Where people live, combined with race and income, are huge factors in why millions of the worst-off Americans have life expectancies typical of developing countries, Murray concluded. Asian-American women, for example, can expect to live 13 years longer than low-income black women in the rural South -- and 21 years longer than inner-city black men -- who have life expectancies similar to those in Third-World nations, the study found.

Health disparities are widely considered the result of minorities and the poor being unable to find or afford good medical care. Murray's county-by-county comparison of life expectancy shows that the reality is far more complex. Despite its long-lived Asian-American women residents, Bergen was not among the top 25 counties nationally for high life expectancy overall. This is because just 11.6 percent of Bergen County residents are Asian, while 82 percent are white and 6 percent are black, Murray said. The Asian-Americans in the study included immigrants and second-generation residents, he said.

Howard Shih, manager of census information at the Asian American Federation of New York, wondered whether wealth plays as much of a role in longevity as ethnic background. "I don't know if it's particularly being Asian or being well-off that's driving those numbers," he said. Each Asian subgroup seems to have a different explanation for its longevity. Raw tuna and green tea keep the Japanese alive, said Hiroyuki Gunji, a chef at Mitsuwa, a Japanese supermarket in Edgewater. East Indians depend on a diet heavy on vegetables and low on red meat , said Ravi Mehrotra, president of the Asian Indian Association of New Jersey. Prayer is the key for Filipinos, many of whom are Roman Catholic, said Nora Trivino, a member of the Filipino American Society of Teaneck. The Korean secret to long life is obvious, said Ji Yun Yoo of Fort Lee. "It has to be kimchi ," she quipped. Florence Chen, president of the New Jersey chapter of the Organization of Chinese Americans, even speculated that Bergen's diversity could help account for longevity. "Bergen County is very racially diverse," said Chen, who recently moved to Somerset County from Tenafly. "Maybe it's easier to be a minority, than, say, in Iowa." Murray analyzed census and mortality data from 1982 to 2001 by county, race, gender and income. He found some distinct groups that he called the "eight Americas": Asian-Americans, with an average per-capita income of $21,566, have a life expectancy of 84.9 years.

* Northland low-income rural whites, $17,758, 79 years.
* Middle America (mostly white), $24,640, 77.9 years.
* Low-income whites in Appalachia, Mississippi Valley, $16,390, 75 years
* Western American Indians, $10,029, 72.7 years.
* Black Middle America, $15,412, 72.9 years.
* Southern low-income rural blacks, $10,463, 71.2 years.
* High-risk urban blacks, $14,800, 71.1 years.

Disparities were most pronounced in young and middle-age adults. A 15-year-old urban black man was 3.8 times more likely to die before age 60 than an Asian-American, for example. Genetic inheritance does not appear to play a large role in these health disparities, Murray said. "The difference we observe in these groups is due to levels of chronic disease in young and middle-age adults, and almost all of that is due to tobacco, alcohol, obesity, cholesterol and diet," he said.

For now, the study has shown, "we have to put our energy into tackling the problem of chronic disease in young and middle-aged adults," he said. Murray's study is important, but not specific enough, said Diane Brown of the University of Medicine and Dentistry of New Jersey. The degree of neighborhood racial segregation and environmental exposure, such as industrial waste and pollution in a community, also influences longevity, said Brown, executive director of the Institute for the Elimination of Health Disparities at the UMDNJ School of Public Health in Newark. "I'm saying there are other factors that also need to be considered," she said. "It doesn't allow us to fully understand all the variation that occurs within the population of the counties." This article includes material from The Associated Press.

http://www.worldhealth.net/news/asia..._nation_s_top_
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It such a great post on aging, i have aging on my face and i try many think but it could not work on my face,i think i should try your tips and lets see is working on my aging or not.

Hi Guys,
Do not take everything as gospel regardless of who says it the worlds oldest people have an average lifespan of 81 years counting both male and female, if you only count females the life expectancy is 83 years, and this currently belongs to the Okinawan elders and an Italian village in the mountains.

Cheers

I admit 5 months later and still seeking that I still have not found the best anti wrinkle/anti aging free skin care trial product yet! But with all these negative reviews, maybe Im not giving these products enough time to produce? Are there any good skin care maintenence products produced from these trials or all they all scams? Please refer me to any good, safe, and legit offers? Thank You!

Acne

you can't stop the aging , but you can slow it with antiaging stuff
it's true that okinawa japan lady is the logest life (in the world)
that because their healthy food , veggie , climate and work every day to maintain their physic
use anything to slow your aging , not your to shorten life , just mind it

sorry i can't give you more information about antiaging product , because it will turn this thread forum into something commercial , just search other people opinion about product that you interest in forum and compare it one to another , or ask your friend how the effect if he/she using it

Effects of L-Carnitine Extract for Human Body

The mission of anti-aging medical science is to living as long as possible in good health and to enable human to maintain quality of life (QOL), and reduce the deterioration of aging. People may use some drugs or supplement for maintaining their body.

Yoshikazu Yonei et al from Anti-Aging Medical Research Center, Kyoto Doshisha University of Japan, have done a research about effects of L-carnitine extract for human body. They used common parameters for investigating and studying the assesments of general physical examination and the influence and safety of dietary supplements, health foods, medical devices, exercose equipment, cosmetics, and obesity. The subjects of the research were middle-aged and older people.

L-carnitine is biologically active form of carnitine, the ammonium compound biosynthesized from the amino acids lysine and methionine. In cell, carnitine is used for transport of fatty acids into the mitochondria of cell during the breakdown of fats to generate the metabolic energy. It protects against degeneration of nerve cells, so it is believed to be useful for preventing loss of short-term memory, Alzheimer’s disease, and depression.

The test, that was held in 8 weeks, resulted that the test group of people had significant improvements in some physical symptoms. It is the actions of amino acids and vitamins contained in the test product.

The test group had improvement effects on dizziness. It is said as the effect of carnitine in cochlear hair cells in ear. Carnitine is known to improve digestive tract movements and to suppress lesions in the gastric mucosal membrane, so it is involved in improving both early satiety and epigastric pain in the test group. Other significant result is improvement of tired eyes and blurry eyes. It may be caused by concentration of carnitine in eye tissue.

But, in the test group, there was significant rise of total cholesterol, fasting blood sugar level, and HbA1c level.

As for oxidation stress markers, lipid peroxides decreased significantly in the test group. Carnitine plays an important role in lipid metabolism and possesses anti-oxidation activity. These findings suggest that the consumption of the supplement can reduce the oxidative damage and some symptoms in the human; however, the effect on QOL was equivocal from the results of the effect on lipid metabolism.

Sources:

Steiber A, Kerner J, Hoppel C (2004). “Carnitine: a nutritional, biosynthetic, and functional perspective”. Mol. Aspects Med. 25 (5-6): 455–73.

Yoshizaku Y, et al (2008). “Effects on the Human Body of a Dietary Supplement Containing L-Carnitine and Garcinia cambogia Extract: A Study using Double-blind Tests”. J Clin Biochem Nutr. 2008 March; 42(2): 89–103.

http://avenueoflife.wordpress.com/20...or-human-body/
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I am a believer in anti-aging, maybe because I am getting close in my early 40's. Anyway, I am looking into more cosmetic approaches as my diet is already pretty good. However, I am not a know it all and welcome any new anti-aging treatments or natural remedies to delay it even more.

wow , thx for sharing with us , please don't mind to post your info or anti-aging link again

Colorectal cancer rates rise most dramatically for adults in their 20s, a study finds

A team of researchers, including Rebecca L. Siegel, manager of surveillance information in the department of surveillance and health policy research at the American Cancer Society, conducted a study of colorectal cancer rates in people younger than 50. Siegel and her colleagues evaluated data collected on approximately 11,000 men and 9,800 women younger than 50 taken from 13 U.S. cancer registries that tracked information from 1992 through 2005. They found that colorectal cancer rates among the men increased 1.5 percent a year, with rates slightly higher -- at 1.6 percent a year -- for women younger than 50. Non-Hispanic white adults were especially at risk: rates rose 3.5 percent a year among men and 2.9 percent a year among women. This compares to overall annual rates across all categories of 2.8 percent and 2.2 percent among American men and women, respectively.

Moreover, the researchers found that every age category -- from 20 to 29, 30 to 39 and 40 to 49 -- experienced an increase. But surprisingly, for young adults between the ages of 20 and 29, rates were the highest: in this age category, rates rose 5.2 percent a year in men and 5.6 percent a year in women. As Siegel points out, in contrast to older populations, for which a drop in new diagnoses has been well established, the rates for younger adults are increasing fairly rapidly. In fact, of the American Cancer Society's estimated 41,000 new cases of rectal cancer this year, Siegel says that number will include approximately 15,000 people younger than 50.

“We aren't sure exactly what's going on," says Siegel. "But, clearly, I think the increased rates among younger adults, while low, are substantial and need some attention. For now we can say that there is obviously an obesity epidemic going on in the U.S., and so that probably has something to do with it. Also, there has been a change in dietary patterns over the past couple of decades, reflected in an increase in fast-food consumption and red meat consumption among young people. But whatever the cause,” she adds, “I would say clinicians should perhaps be more aware of the risks involved when younger people in their 20s and 30s come in with symptoms for what could be colorectal cancer. This current finding suggests that perhaps clinicians need to act on the risk a little bit more aggressively.”

Dr. Warren Enker, a colorectal surgeon and vice chairman of surgery at Beth Israel Medical Center in New York City, isn't surprised by the results of the study. "A dietary cause makes sense," he says. "If you take kids who are in an environment where the general caloric intake is higher, a sedentary lifestyle is more prevalent than it was 30 years ago and the type of food they're eating -- as regards red meat -- is higher, and then you put all of those things together, then there is no surprise that you have a rising incidence of colon cancer among younger people relative to others." However, other cancer colon specialists believe that additional research needs to be conducted to evaluate other potential factors that could influence colorectal cancer rates, such as smoking history and socioeconomic background.

News Release: Colorectal cancer rates rising for under 50 set www.health.usnews.com June 8, 2009

http://www.worldhealth.net/news/colo...e_most_dramat/
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My mom has has some wrinkles and I don't know many anti aging creams she has tried but non seem to work. But one thing for sure is that shes not giving up.

But I'm sure they are good ones that work that why its good business for anti aging companies.