Benefits of Vitamin E in Heart Disease?

Written By: Gloria Tsang, RD

Title: Founding Registered Dietitian

Alumni: University of British Columbia

Last Updated on:

Can Vitamin E Protect Your Heart?

Vitamin E in Heart Disease – Previous findings

Numerous preliminary and observational studies have looked at the role and benefits of Vitamin E supplements in heart disease. Some previous studies, such as the Nurse Study in 1993 involving 90,000 nurses, associated Vitamin E supplements to lower rate of coronary heart disease by 30 – 40%. Another observational study in Finland involving over 5000 people also suggested that Vitamin E supplements was associated with lower death rate from heart disease.

Vitamin E in Heart Disease – New findings

Until recently, a few randomized clinical studies could not confirm the role of Vitamin E supplements in heart disease prevention. A large-scale trial The Heart Outcomes Prevention Evaluation (HOPE) Study followed 95,000 patients for 4.5 years who were at high risk for heart attack or stroke. In this clinical trial, patients who received 400 IU of vitamin E daily did not experience significantly fewer cardiovascular events or hospitalizations for heart failure or chest pain when compared to those who received the placebo.

Johns Hopkins University also performed a meta-analysis of 19 clinical studies and they published their findings in January 2005. The result showed that a daily dose of 400 IU or more Vitamin E increased the risk of death from all cause.

In addition, the Women’s Healthy Study published in July 2005 also showed that 600 IU of natural-source vitamin E also does little or nothing to prevent heart disease in healthy women

What is Vitamin E?

Vitamin E is a fat-soluble vitamin. It existed in various forms; alpha-tocopherol is the most active form of Vitamin E in our bodies. Alpha-tocopherol is a powerful antioxidant, protecting us from free radical damage. Free radical damage is often thought to contribute to the development of cancer and heart disease.

Vitamin E in Food

Vitamin E can be found in vegetable oils, nuts, and green leafy vegetables.

Vitamin E Key Message: More and more studies showed that >400 IU Vitamin E supplements did not prevent cardiovascular disease or cancer. Indeed, this dosage may cause harm. The Hopkins analysis found that taking 200 IU or less may offer benefit in heart health.

In August 2004, the American Heart Association advised against taking supplements of any antioxidant vitamin (Vitamin E, C or beta carotene) to reduce heart disease risk. Instead, AHA encouraged getting these vitamins from a healthy diet.

Caution: do not exceed 1,500 IU per day because Vitamin E can act as an anticoagulant and increase the risk of bleeding problems. In addition, avoid Vitamin E supplement if you are using anticlotting drugs such as warfarin and aspirin.


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